Endocrine Abstracts

Purpose: Disruption in thyroid hormone homeostasis by environmental chemicals during the prenatal and/or neonatal period might lead to developmental disorders since thyroid hormones (T3/T4) play a critical role in growth and the differentiation of many tissues including the central nervous system. Neonatally given T3 or T4 disrupts the thyroid hormone system resulting in decreased serum T4 level in the adulthood in rats. In the present study, changes in gene expression profile...